Reversade, B., Kuroda, H., Lee, H., Mays, A. Neural induction: old problem, new findings, yet more questions. Integration of Smad and MAPK pathways: a link and a linker revisited. Default neural induction: neuralization of dissociated Xenopus cells is mediated by Ras/MAPK activation. ![]() Kuroda, H., Fuentealba, L., Ikeda, A., Reversade, B. Induction of epidermis and inhibition of neural fate by Bmp-4. Neural differentiation of Xenopus laevis ectoderm takes place after disaggregation and delayed reaggregation without inducer. Neural induction in Xenopus: requirement for ectodermal and endomesodermal signals via Chordin, Noggin, β-catenin, and Cerberus. Depletion of three BMP antagonists from Spemann's organizer leads to a catastrophic loss of dorsal structures. The organizer secreted factors Chordin and Noggin are required for forebrain development in the mouse. Chordin is required for the Spemann organizer transplantation phenomenon in Xenopus embryos. Oelgeschläger, M., Kuroda, H., Reversade, B. Morpholino oligos: making sense of antisense? Dev. The structure of the follistatin:activin complex reveals antagonism of both Type I and Type II receptor binding. The Spemann organizer signal noggin binds and inactivates bone morphogenetic protein 4. Dorsoventral patterning in Xenopus: inhibition of ventral signals by direct binding of Chordin to BMP-4. Regulation of neural induction by the chd and BMP-4 antagonistic patterning signals in Xenopus. Neural differentiation of ectoderm through exposure to saline solution. Neural diffferentiation without organizer. Versuche zur Analyse der Induktionsmittel in der Embryonalentwicklung. Requirement for anti-dorsalizing morphogenetic protein in organizer patterning. Anti-dorsalizing morphogenetic protein is a novel TGF-β homolog expressed in the Spemann organizer. Dorsal–ventral patterning and neural induction in Xenopus embryos. The establishment of Spemann's organizer and patterning of the vertebrate embryo. Follistatin, an antagonist of activin, is expressed in the Spemann organizer and displays direct neuralizing activity. Neural induction by secreted polypeptide noggin. Expression cloning of noggin, a new dorsalizing factor localized to the Spemann organizer in Xenopus embryos. ed.) 581–589 (Cold Spring Harbor Laboratory, New York, 2004). Xenopus chordin: a novel dorsalizing factor activated by organizer-specific homeobox genes. Sasai, Y., Lu, B., Steinbeisser, H., Geissert, D., Gont, L. The homeobox gene goosecoid controls cell migration in Xenopus embryos. A novel, activin-inducible, blastopore lip-specific gene of Xenopus laevis contains a fork head DNA-binding domain. ![]() The LIM domain-containing homeo box gene Xlim-1 is expressed specifically in the organizer region of Xenopus gastrula embryos. Molecular nature of Spemann's organizer: the role of the Xenopus homeobox gene goosecoid. laevis gene expressed during early embryogenesis coding for a peptide region homologous to Drosophila homeotic genes. The Heritage of Experimental Embryology: Hans Spemann and the Organizer (Oxford Univ., Oxford, UK, 1988).Ĭarrasco, A. Induction of embryonic primordia by implantation of organizers from a different species. (ed.) Gastrulation (Cold Spring Harbor Laboratory, New York, 2004). ![]() Experiments on the development of the fore-limb of Amblystoma, a self-differentiating equipotential system. Half embryos and whole embryos from one of the first two blastomeres. Embryonic Development and Induction (Yale Univ.
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